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Associate Director, Project Lead - Gene Editing
at Vertex Pharmaceuticals Inc (US)
Watertown, MA

Associate Director, Project Lead - Gene Editing
at Vertex Pharmaceuticals Inc (US)
Watertown, MA

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Description

DESCRIPTION

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat-and even cure-several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex's continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

KEY RESPONSIBILITIES

  • Assume project leader responsibility for in vitro, ex vivo and in vivo studies to advance our portfolio of CRISPR-based gene editing therapies to treat neuromuscular diseases.
  • Participate in the development of novel gene editing strategies and approaches.
  • Oversee study design and execution, data analysis and report writing, as well as CRO management for outsourced research activities.
  • Assume project responsibilities and effectively present updates to the senior leadership team.
  • Effectively collaborate with a fully integrated team to facilitate the success of projects.

REQUIREMENTS

  • A PhD in a relevant biological discipline and 7+ years or equivalent of post-doc/pharmaceutical industry experience.
  • Ability to lead, supervise and evaluate an interdisciplinary research team.
  • Excellent strategic planning and organization skills.
  • Deep understanding of gene therapy, genomics, molecular pharmacology and drug development.
  • Working experience with AAV vectors and/or CRISPR/Cas9 system.
  • Familiarity with the preclinical regulatory requirements for gene therapy/editing programs.
  • Excellent communication skills with the proven ability to work effectively as a member of a multidisciplinary team.

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