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Research Scientist, Computational Biology (Methods Development)
at Vertex Pharmaceuticals Inc (US)
Cambridge, MA

Research Scientist, Computational Biology (Methods Development)
at Vertex Pharmaceuticals Inc (US)
Cambridge, MA

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Do you want to play a critical role in the development of transformative medicine for human diseases? We are seeking a computational biologist with expertise in the development of computational methods for analysis of large-scale genomic data to join Vertex's research site in Boston, MA. This position is part of a growing global Computational Genomics team focused on developing novel, innovative gene editing and genetic therapy treatments for serious human diseases. Past success of this team includes bringing forward CTX-001, a CRISPR gene editing treatment for Sickle Cell Disease, to the first company-sponsored CRISPR clinical trial in the United States. A key task for you will be to develop robust computational software tools and systems that will be leveraged for the development of genetic therapies. Experience in analyzing genomics data and developing bioinformatics tools is essential, as are strong software engineering skills.

Key responsibilities:

  • Design, build, and improve state-of-the-art, generalizable, and robust genomics software tools to enable the lifecycle of genetic therapy development
  • Innovate new algorithms and analysis methods to answer biological questions as needs arise in novel therapeutic areas and approaches
  • Collaborate with and advise team members in designing studies, developing analyses, and applying methods to answer scientific questions
  • Stay up-to-date with cutting-edge advancements in the fast-paced fields of gene editing and genetic therapies, bringing them in-house or building upon them as appropriate
  • Communicate effectively with both technical and non-technical team members
  • Follow best practices of team software development, including documentation, testing, version control, code reviews, programming style standards, and modular software design

Minimum Qualifications:

  • PhDdegree in computer science, computational biology, bioinformatics, or a related field; B.S. or M.S. with strong background and relevant experience may also be considered
  • A proven track record in method development for and analysis of genomic and next-generation sequencing (NGS) data
  • Strong programming skills, with the ability to write clear, maintainable, and well-tested code
  • Expertise in Linux/Unix environments and Python
  • Detail-oriented and self-motivated approach to problem solving with excellent reasoning skills
  • A positive attitude that enthusiastically tackles and overcomes challenges, with excellent organizational and time-management skills to prioritize needs and get things done
  • A team-oriented growth mindset that welcomes feedback from others and supports other team members

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